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1

Application of the Convection–Dispersion Equation to Modelling Oral Drug Absorption

Jan I. Freijer, Teun M. Post, Bart A. Ploeger, Joost DeJongh, Meindert Danhof

Journal:

Bulletin of Mathematical Biology

Year:

2007

Language:

english

File:

PDF, 245 KB

english, 2007

2

The costs of disease related malnutrition in hospitalized children

Freijer, Karen, van Puffelen, Esther, Joosten, Koen F., Hulst, Jessie M., Koopmanschap, Marc A.

Journal:

Clinical Nutrition ESPEN

Year:

2017

Language:

english

File:

PDF, 315 KB

english, 2017

3

The Economic Value of Enteral Medical Nutrition in the Management of Disease-Related Malnutrition: A Systematic Review

Freijer, Karen, Bours, Martijn J.L., Nuijten, Mark J.C., Poley, Marten J., Meijers, Judith M.M., Halfens, Ruud J.G., Schols, Jos M.G.A.

Journal:

Journal of the American Medical Directors Association

Year:

2014

Language:

english

File:

PDF, 576 KB

english, 2014

4

Analytical solutions of the convection–dispersion equation applied to transport of pesticides in soil columns

J.I. Freijer, E.J.M. Veling, S.M. Hassanizadeh

Journal:

Environmental Modelling & Software

Year:

1998

Language:

english

File:

PDF, 249 KB

english, 1998

5

The economic costs of disease related malnutrition

Freijer, Karen, Tan, Siok Swan, Koopmanschap, Marc A., Meijers, Judith M.M., Halfens, Ruud J.G., Nuijten, Mark J.C.

Journal:

Clinical Nutrition

Year:

2013

Language:

english

File:

PDF, 154 KB

english, 2013

6

Selected Nutrients and Their Implications for Health and Disease across the Lifespan: A Roadmap

Péter, Szabolcs, Eggersdorfer, Manfred, van Asselt, Dieneke, Buskens, Erik, Detzel, Patrick, Freijer, Karen, Koletzko, Berthold, Kraemer, Klaus, Kuipers, Folkert, Neufeld, Lynnette, Obeid, Rima, Wiese

Journal:

Year:

2014

Language:

english

File:

PDF, 585 KB

english, 2014

7

Dioxins, dioxin-like PCBs and non-dioxin-like PCBs in foodstuffs: occurrence and dietary intake in The Netherlands

A.J Baars, M.I Bakker, R.A Baumann, P.E Boon, J.I Freijer, L.A.P Hoogenboom, R Hoogerbrugge, J.D van Klaveren, A.K.D Liem, W.A Traag, J de Vries

Journal:

Toxicology Letters

Year:

2004

Language:

english

File:

PDF, 108 KB

english, 2004

8

Analysis of the health economic impact of medical nutrition in the Netherlands

Freijer, K, Nuijten, M J C

Journal:

European Journal of Clinical Nutrition

Year:

2010

Language:

english

File:

PDF, 246 KB

english, 2010

9

Modelling exposure of the Dutch population to air pollution

J.I Freijer, H.J.Th Bloemen, S de Loos, M Marra, P.J.A Rombout, G.M Steentjes, M.P van Veen

Journal:

Journal of Hazardous Materials

Year:

1998

Language:

english

File:

PDF, 86 KB

english, 1998

10

Optimizing the glutamatergic challenge model for psychosis, using S(+)-ketamine to induce psychomimetic symptoms in healthy volunteers

Kleinloog, D., Uit den Boogaard, A., Dahan, A., Mooren, R., Klaassen, E., Stevens, J., Freijer, J., van Gerven, J.

Journal:

Journal of Psychopharmacology

Year:

2015

Language:

english

File:

PDF, 835 KB

english, 2015

11

MON-LB337: The Additional Costs of Disease Related Malnutrition in Hospitalized Children

Freijer, K., Puffelen, E.V., Joosten, K.F., Hulst, J.M., Koopmanschap, M.A.

Journal:

Clinical Nutrition

Year:

2017

Language:

english

File:

PDF, 60 KB

english, 2017

12

Medical Nutrition Terminology and Regulations in the United States and Europe—A Scoping Review: Report of the ISPOR Nutrition Economics Special Interest Group

Freijer, Karen, Volger, Sheri, Pitter, János G., Molsen-David, Elizabeth, Cooblall, Clarissa, Evers, Silvia, Hiligsmann, Mickaël, Danel, Aurelie, Lenoir-Wijnkoop, Irene

Journal:

Value in Health

Year:

2018

Language:

english

File:

PDF, 1.07 MB

english, 2018

13

Mineralization of Hydrocarbons in Soils under Decreasing Oxygen Availability

Freijer, Jan I.

Journal:

Journal of Environmental Quality

Year:

1996

Language:

english

File:

PDF, 229 KB

english, 1996

14

Disease System Analysis: Basic Disease Progression Models in Degenerative Disease

Teun M. Post, Jan I. Freijer, Joost DeJongh, Meindert Danhof

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 777 KB

english, 2005

15

Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex

Marian Geldof, Jan I. Freijer, Lambertus A. Peletier, Ludy van Beijsterveldt, Meindert Danhof

Journal:

European Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 695 KB

english, 2008

16

Comparison of Six Methods To Determine Unsaturated Soil Hydraulic Conductivity

Stolte, J., Halbertsma, J. M., Veerman, G. J., Wösten, J. H. M., Freijer, J. I., Bouten, W., Dirksen, C., Van Dam, J. C., Van den Berg, J. A.

Journal:

Soil Science Society of America Journal

Year:

1994

Language:

english

File:

PDF, 338 KB

english, 1994

17

Relation between Bioavailability and Fuel Oil Hydrocarbon Composition in Contaminated Soils

de Jonge, H., Freijer, J. I., Verstraten, J. M., Westerveld, J., van der Wielen, F. W. M.

Journal:

Environmental Science & Technology

Year:

1997

Language:

english

File:

PDF, 139 KB

english, 1997

18

The application of TDR in laboratory column experiments

Heimovaara, T.J., Freijer, J.I., Bouten, W.

Journal:

Soil Technology

Year:

1993

Language:

english

File:

PDF, 592 KB

english, 1993

19

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development

Ashley Strougo, Thomas Eissing, Ashraf Yassen, Stefan Willmann, Meindert Danhof, Jan Freijer

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2012

Language:

english

File:

PDF, 311 KB

english, 2012

20

Calibration of Jointed Tube Model for the Gas Diffusion Coefficient in Soils

Freijer, Jan I.

Journal:

Soil Science Society of America Journal

Year:

1994

Language:

english

File:

PDF, 377 KB

english, 1994

21

Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of β blockers using a new mechanism-based PK–PD modelling approach

T.J. van Steeg, V.B. Boralli, E.H.J. Krekels, P. Slijkerman, J. Freijer, M. Danhof, E.C.M. de Lange

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 205 KB

english, 2009

22

Pharmacokinetic Modeling of Non-Linear Brain Distribution of Fluvoxamine in the Rat

Marian Geldof, Jan Freijer, Ludy van Beijsterveldt, Meindert Danhof

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 540 KB

english, 2008

23

Response to letter to the editor from Dr. Mahmood

Strougo, A., Yassen, A., Danhof, M., Freijer, J.

Journal:

Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 97 KB

english, 2015

24

Analysis of Lobar Differences in Particle Deposition in the Human Lung

Subramaniam, Ravi P., Asgharian, Bahman, Freijer, Jan I., Miller, Frederick J., Anjilvel, Satish

Journal:

Inhalation Toxicology

Year:

2003

Language:

english

File:

PDF, 183 KB

english, 2003

25

Mechanism-Based Pharmacodynamic Modeling of S(-)-Atenolol: Estimation of in Vivo Affinity for the 1-Adrenoceptor with an Agonist-Antagonist Interaction Model

van Steeg, T. J., Freijer, J., Danhof, M., de Lange, E. C. M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2007

Language:

english

File:

PDF, 315 KB

english, 2007

26

Effect of altered AGP plasma binding on heart rate changes by S(−)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (KB,vivo)

T.J. van Steeg, E.H.J. Krekels, J. Freijer, M. Danhof, E.C.M. de Lange

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 203 KB

english, 2010

27

A Semiphysiological Population Model for Prediction of the Pharmacokinetics of Drugs under Liver and Renal Disease Conditions

Strougo, A., Yassen, A., Krauwinkel, W., Danhof, M., Freijer, J.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

28

The Budget Impact of Oral Nutritional Supplements for Disease Related Malnutrition in Elderly in the Community Setting

Freijer, Karen, Nuijten, Mark J. C., Schols, Jos M. G. A.

Journal:

Frontiers in Pharmacology

Year:

2012

Language:

english

File:

PDF, 428 KB

english, 2012

29

Extensions to the Visual Predictive Check to facilitate model performance evaluation

Teun M. Post, Jan I. Freijer, Bart A. Ploeger, Meindert Danhof

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2008

Language:

english

File:

PDF, 498 KB

english, 2008

30

Pharmacokinetic–pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior

Marian Geldof, Jan Freijer, Ludy van Beijsterveldt, Patrick C.M. Vermote, Anton A. Megens, Meindert Danhof

Journal:

European Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 810 KB

english, 2007

31

The view of European experts regarding health economics for medical nutrition in disease-related malnutrition

Freijer, K, Lenoir-Wijnkoop, I, Russell, C A, Koopmanschap, M A, Kruizenga, H M, Lhachimi, S K, Norman, K, Nuijten, M J C, Schols, J M G A

Journal:

European Journal of Clinical Nutrition

Year:

2015

Language:

english

File:

PDF, 394 KB

english, 2015

32

A model for the effect on health of repeated exposure to ozone

J.I. Freijer, J.C.H. van Eijkeren, L. van Bree

Journal:

Environmental Modelling & Software

Year:

2002

Language:

english

File:

PDF, 121 KB

english, 2002

33

Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux

D Groenendaal, J Freijer, D de Mik, M R Bouw, M Danhof, E C M de Lange

Journal:

British Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 272 KB

english, 2007

34

Population pharmacokinetic model of fluvoxamine in rats: Utility for application in animal behavioral studies

Marian Geldof, Jan Freijer, Ludy van Beijsterveldt, Philip Timmerman, Abdellah Ahnaou, Wilhelmus H.I.M. Drinkenburg, Meindert Danhof

Journal:

European Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 632 KB

english, 2007

35

Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG

D Groenendaal, J Freijer, D de Mik, M R Bouw, M Danhof, E C M de Lange

Journal:

British Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 260 KB

english, 2007

36

Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model

Flemming R. Cassee, Hans Muijser, Evert Duistermaat, Jan J. Freijer, Kees B. Geerse, Jan C. Marijnissen, Josje H. Arts

Journal:

Archives of Toxicology

Year:

2002

Language:

english

File:

PDF, 240 KB

english, 2002

37

Pharmacokinetic-pharmacodynamic modelling of S(−)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint

T J van Steeg, J Freijer, M Danhof, E C M de Lange

Journal:

British Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 237 KB

english, 2007

38

Risk Assessment in Extrapolation of Pharmacokinetics from Preclinical Data to Humans

Zvi Teitelbaum, Thierry Lave, Jan Freijer, Adam F. Cohen

Journal:

Clinical Pharmacokinetics

Year:

2010

Language:

english

File:

PDF, 230 KB

english, 2010

39

Pharmacokinetic–pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex

M Geldof, J I Freijer, L Van Beijsterveldt, X Langlois, M Danhof

Journal:

British Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 213 KB

english, 2008

40

Novel Δ9-tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects

Linda E. Klumpers, Tim L. Beumer, Johan G. C. van Hasselt, Astrid Lipplaa, Lennard B. Karger, H. Daniël Kleinloog, Jan I. Freijer, Marieke L. de Kam, Joop M. A. van Gerven

Journal:

British Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

41

Modeling the Gas Diffusion Coefficient in Analogy to Electrical Conductivity Using a Capillary Model

Weerts, Albrecht H., Freijer, Jan I., Bouten, Willem

Journal:

Soil Science Society of America Journal

Year:

2000

Language:

english

File:

PDF, 213 KB

english, 2000

42

Profiling the subjective effects of Δ 9 -tetrahydrocannabinol using visual analogue scales

Kleinloog, Daniël, Roozen, Frits, De Winter, Willem, Freijer, Jan, Van Gerven, Joop

Journal:

International Journal of Methods in Psychiatric Research

Year:

2014

Language:

english

File:

PDF, 587 KB

english, 2014

43

Assessing mineralization rates of petroleum hydrocarbons in soils in relation to environmental factors and experimental scale

J. I. Freijer, H. Jonge, W. Bouten, J. M. Verstraten

Journal:

Year:

1996-1997

Language:

english

File:

PDF, 1.06 MB

english, 1996-1997

44

An example of optimal phase II design for exposure response modelling

Alan Maloney, Marloes Schaddelee, Jan Freijer, Walter Krauwinkel, Marcel van Gelderen, Philippe Jacqmin, Ulrika S. H. Simonsson

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2010

Language:

english

File:

PDF, 446 KB

english, 2010

45

Monitoring Prednisolone and Prednisone in Saliva

Teeninga, Nynke, Guan, Zheng, Freijer, Jan, Ruiter, An F. C., Ackermans, Mariëtte T., Kist-van Holthe, Joana E., van Gelder, Teun, Nauta, Jeroen

Journal:

Therapeutic Drug Monitoring

Year:

2013

Language:

english

File:

PDF, 473 KB

english, 2013

46

Pharmacokinetics and Pharmacodynamics of Orally Administered Clonidine: A Model-Based Approach

Klein, R.H., Alvarez-Jimenez, R., Sukhai, R.N., Oostdijk, W., Bakker, B., Reeser, H.M., Ballieux, B.E.P.B., Hu, P., Klaassen, E.S., Freijer, J., Burggraaf, J., Cohen, A.F., Wit, J.M.

Journal:

Hormone Research in Paediatrics

Year:

2013

Language:

english

File:

PDF, 324 KB

english, 2013

47

Absorption model based on transport physics theory applied to paracetamol

Journal:

Clinical Pharmacology & Therapeutics

Year:

2004

Language:

english

File:

PDF, 28 KB

english, 2004

48

A comparison of field methods for measuring soil carbon dioxide evolution: Experiments and simulation

J. I. Freijer, W. Bouten

Journal:

Year:

1991

Language:

english

File:

PDF, 648 KB

english, 1991

49

Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics

Dorien Groenendaal, Jan Freijer, Andrea Rosier, Dennis de Mik, Glynis Nicholls, Anne Hersey, Andrew D. Ayrton, Meindert Danhof, Elizabeth C.M. de Lange

Journal:

European Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

50

Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics

Heuberger, Jules A. A. C., Guan, Zheng, Oyetayo, Olubukayo-Opeyemi, Klumpers, Linda, Morrison, Paul D., Beumer, Tim L., van Gerven, Joop M. A., Cohen, Adam F., Freijer, Jan

Journal:

Clinical Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 905 KB

english, 2015

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